CarbonCool® Clinical Studies


Safety and Efficacy of CarbonCool Half-Body Vest for HAZMAT Decontamination Crews Wearing Personal Protective Equipment: A Pilot Study

Personal protective equipment (PPE) are essential for medical personnel responding to hazardous materials (HAZMAT) incidents. However, their impermeable design causes increased physiological strain and reduced thermoregulation, limiting work times and causing heat-related illnesses (HRI). Use of wearable cooling devices slow heat accumulation and have been shown to reduce thermal and cardiovascular strain in such situations.


Novel wearable cooling device for early initiation of targeted temperature management in the Emergency Department

Targeted temperature management (TTM) is an important component of post-cardiac arrest care. Studies have suggested that cooling is associated with better outcomes. The aim of this study was to evaluate the cooling efficacy of a protocol including a novel cooling device in the Emergency Department.


A pilot study to Evaluate the Potential of Using a CarbonCool Vest in Reduction of Heat Stress among First Responders Donned in CLD500 Decontamination Suit

This pilot study aims to evaluate the potential of CarbonCool vest in reduction of heat stress among first responders donned in CLD500 decontamination suit while carrying out moderate-intensity functional exercises.


Heat Injury Management in the SAF 

In May 2018, MINDEF commissioned an External Review Panel on Heat Injury Management (hereinafter referred to as “The Panel”) to examine the SAF’s heat injury policies and processes. The Panel was headed by A/PROF MARK LEONG KWOK FAI, Senior Consultant, Department of Emergency Medicine, SGH, who was supported by: A/PROF MARCUS ONG ENG HOCK, Senior Consultant, Department of Emergency Medicine, SGH; A/PROF KELVIN CHEW TAI LOON, Director and Senior Consultant, Changi Sport Medicine Centre, CGH; DR TEOH CHIN SIM, Director and Senior Consultant, Sport Medicine Centre, KTPH; and A/PROF JASON LEE KAI WEI, Programme Director, Human Performance Programme, Defence Medical & Environment Research Institute, DSO National Laboratories.


Preliminary Testing of CarbonCool™ CoolingSystem for HAZMAT Decontamination 

Frontline healthcare staff have to don thick layers of personal protective equipment (PPE) to decontaminate patients for Hazmat operations and training and Long periods in PPE may trigger heat stress or fatigue. A study was conducted to evaluate if the use of the CarbonCool® System with PPE was useful in reducing physiological stress during Hazmat training.



Scalp cooling (SC) is hypothesized to reduce the severity of chemotherapy-induced alopecia (CIA) via vasoconstriction, limiting the drug uptake to the hair follicle matrixcells. However, no formal studies have been conducted to evaluate whether chemotherapy concentrations in the hair follicles are truly reduced after SC.